Medizinische Universität Graz - Research portal

Navigation/Search

BEUBLER, E; KOLLAR, G.
PROSTAGLANDIN-MEDIATED ACTION OF SENNOSIDES
PHARMACOLOGY. 1988; 36: 85-91. Doi: 10.1159/000138425
Web of Science PubMed FullText FullText_MUG Google Scholar

Leading authors Med Uni Graz: Beubler Eckhard
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: The aim of this study was to investigate whether prostaglandins (PG) are involved in the mediation of sennoside-induced colonic fluid and electrolyte secretion. Oral administration of senna pod extract dose-dependently reversed net absorption of water, sodium and chloride to net secretion, increased potassium secretion and stimulated the release of PGE2 into the colonic lumen. Inhibition of PG biosynthesis by pretreatment of the rats with indomethacin significantly inhibited the effects of senna pod extract both on net fluid transport and on PGE2 release. The inhibitory effect of indomethacin on net fluid transport induced by senna pod extract was dose-dependent. It is concluded that sennosides exert their laxative action at least partially via stimulation of colonic fluid and electrolyte secretion, and that this secretion is mediated by stimulation of endogenous PGE2 formation.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Anthraquinones - pharmacology; Body Fluids - drug effects; Cathartics - pharmacology; Chlorides - metabolism; Colon - drug effects; Dinoprostone - drug effects; Female - drug effects; Prostaglandins E - physiology; Rats - physiology; Rats, Inbred Strains - physiology; Sodium - metabolism