Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Massone, C; Crisman, G; Kerl, H; Cerroni, L.
The prognosis of early mycosis fungoides is not influenced by phenotype and T-cell clonality.
Br J Dermatol. 2008; 159(4): 881-886.
Doi: 10.1111/j.1365-2133.2008.08761.x
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- Führende Autor*innen der Med Uni Graz
- Cerroni Lorenzo
- Massone Cesare
- Co-Autor*innen der Med Uni Graz
- Kerl Helmut
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- Abstract:
- BACKGROUND: The influence of phenotype and detection of clonality on prognosis in early mycosis fungoides has never been addressed in large studies. OBJECTIVES: To correlate immunophenotype and detection of clonality with clinical outcome. METHODS: We analysed 73 biopsy specimens from 68 patients with early mycosis fungoides (stage Ia or Ib) and at least 10 years of follow up (or dead of disease). RESULTS: Four phenotypic groups could be identified: group A (alpha/beta+ CD4+ CD8- TIA1-), 51 patients; median survival time 160 months; group B (alpha/beta+ CD4- CD8+ TIA1+), 10 patients; median survival time 195 months; group C (alpha/beta- CD4- CD8+/- TIA1+), five patients; median survival time 165 months; and group D (alpha/beta+ CD4- CD8- TIA1-), two patients; median survival time 130 months. Survival curves did not show statistical differences among the groups. Monoclonality was detected in 36 of 67 tested biopsies (54%), and statistical analyses did not show prognostic differences between the clonal and nonclonal cases. CONCLUSIONS: We conclude that cytotoxic phenotype and detection of monoclonal T-cell receptor-gamma gene rearrangement in early lesions of mycosis fungoides do not have any prognostic significance.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Biopsy - methods
- Chi-Square Distribution -
- Child -
- Clone Cells - immunology
- Female -
- Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor - genetics
- Humans -
- Male -
- Middle Aged -
- Mycosis Fungoides - genetics Mycosis Fungoides - immunology Mycosis Fungoides - pathology
- Phenotype -
- Polymerase Chain Reaction - methods
- Prognosis -
- Skin Neoplasms - genetics Skin Neoplasms - immunology Skin Neoplasms - pathology
- T-Lymphocytes - immunology
- Find related publications in this database (Keywords)
- clonality
- mycosis fungoides
- phenotype
- polymerase chain reaction