Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sundl, I; Roob, JM; Meinitzer, A; Tiran, B; Khoschsorur, G; Haditsch, B; Holzer, H; Winklhofer-Roob, BM.
Antioxidant status of patients on peritoneal dialysis: associations with inflammation and glycoxidative stress.
Perit Dial Int. 2009; 29(1): 89-101.
Doi: 10.1177/089686080902900113
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- Co-Autor*innen der Med Uni Graz
- Holzer Herwig
- Khoschsorur Gholamali
- Meinitzer Andreas
- Roob Johannes
- Tiran Beate
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- Abstract:
- BACKGROUND: Patients on peritoneal dialysis (PD) frequently exhibit oxidant-antioxidant imbalance, advanced glycation end-product overload, and subclinical inflammation but the interrelations between these pathophysiological changes have not been fully elucidated. SUBJECTS AND METHODS: To study possible associations, a cross-sectional study of antioxidant status, glycoxidative stress, and inflammation, using HPLC and ELISA methods, was undertaken in 37 PD patients and age- and sex-matched healthy controls. RESULTS: Plasma ascorbate concentrations were low in patients not taking at least low-dose vitamin C supplements. In patients taking vitamin C supplements, there was a positive relation between ascorbate and pentosidine concentrations. Vitamin E and carotenoid concentrations were comparable between patients and controls, while lycopene and lutein/zeaxanthin concentrations were lower. Interleukin-6, C-reactive protein (CRP), and pentosidine concentrations were elevated in PD patients. beta-Cryptoxanthin, lycopene, and lutein/zeaxanthin concentrations were inversely related to interleukin-6 concentrations. beta-Cryptoxanthin concentrations were also inversely related to CRP concentrations. Pentosidine showed a low dialysate-to-plasma ratio, indicating low peritoneal clearance. Pentosidine concentrations increased with duration of PD therapy, while alpha- and beta-carotene concentrations decreased. Malondialdehyde concentrations were elevated compared to controls but remained within the normal range. Retinol concentrations decreased with PD therapy and were inversely related to interleukin-6 and CRP concentrations. CONCLUSIONS: Low-dose vitamin C supplements and a carotenoid-rich diet should be recommended for PD patients to maintain normal antioxidant status and efficiently counteract the chronic inflammatory response, rather than high doses of vitamin C, which could play a role as a precursor of pentosidine.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Antioxidants - metabolism
- Ascorbic Acid - administration and dosage
- C-Reactive Protein - metabolism
- Chromatography, High Pressure Liquid -
- Cross-Sectional Studies -
- Dietary Supplements -
- Dose-Response Relationship, Drug -
- Enzyme-Linked Immunosorbent Assay -
- Female -
- Follow-Up Studies -
- Glycosylation -
- Humans -
- Inflammation - blood
- Kidney Failure, Chronic - blood Kidney Failure, Chronic - therapy
- Male -
- Middle Aged -
- Oxidative Stress - drug effects Oxidative Stress - physiology
- Peritoneal Dialysis - methods
- Prognosis -
- Vitamins - administration and dosage
- Find related publications in this database (Keywords)
- Advanced glycation end products
- ascorbate
- carotenoids
- interleukin-6
- malondialdehyde
- oxidative stress
- pentosidine