Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Horejsi, R; Estelberger, W; Mlekusch, W; Möller, R; Ottl, K; Vrecko, K; Reibnegger, G.
Effects of pteridines on chloramine-T-induced growth inhibition in E. coli strains: correlations with molecular structure.
Free Radic Biol Med. 1996; 21(2):133-138
Doi: 10.1016%2F0891-5849%2896%2900015-9
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- Führende Autor*innen der Med Uni Graz
- Horejsi Renate
- Reibnegger Gilbert
- Co-Autor*innen der Med Uni Graz
- Möller Reinhard
- Öttl Karl
- Vrecko Karoline
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- Abstract:
- Little is known about the biological significance of most pteridines, despite their ubiquitous occurrence in living cells. Seventeen different pteridines were tested for their ability to modulate the growth inhibitory effect of the disinfectant chloramine-T on three different strains of Escherichia coli bacteria. We found striking differences between the pteridine derivatives: whereas aromatic pterins with a hydroxy function at side chain atom C2' increased the growth inhibition, those with a 7,8-dihydro structure exerted a suppressive effect. These results are in excellent agreement with previously observed effects of pteridine derivatives on chloramine-T-induced luminol-dependent chemiluminescence, and together, are highly suggestive of a general interaction of these compounds with oxygen or chlorine free radicals. This interaction is likely to have biological significance and might offer an explanation for the widespread occurrence of pteridines.
- Find related publications in this database (using NLM MeSH Indexing)
- Anti-Infective Agents, Local - pharmacology
- Chemiluminescent Measurements - pharmacology
- Chloramines - pharmacology
- Disinfectants - pharmacology
- Escherichia coli - drug effects
- Free Radical Scavengers - drug effects
- Free Radicals - drug effects
- Luminol - pharmacology
- Molecular Structure - pharmacology
- Pteridines - chemistry
- Structure-Activity Relationship - chemistry
- Tosyl Compounds - pharmacology
- Find related publications in this database (Keywords)
- Escherichia-Coli Bacteria
- Growth Inhibition
- Chloramine-T
- Free Radicals
- Pterins
- Lumazine