Medizinische Universität Graz - Research portal
Selected Publication:
Fröhlich, L; Liu, Z; Beier, DR; Lanske, B.
Genomic structure and refined chromosomal localization of the mouse Ptch2 gene.
Cytogenet Genome Res. 2002; 97(1-2): 106-110.
Doi: 10.1159/000064064
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Fröhlich Leopold F.
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The vertebrate Patched 2 (Ptch2) gene encodes a putative membrane-embedded protein which may have roles in Hedgehog signaling during development and in tumorigenesis. We determined the genomic structure of the mouse Ptch2 gene and show that Ptch2 is composed of 22 exons spanning approximately 18 kb of genomic DNA. The exon-intron boundaries were found to be conserved within the human and mouse Ptch2 genes. Analysis of the 5' flanking region revealed a CpG island, the putative promoter region and the transcriptional start site while a polyadenylation signal as well as a mRNA destabilizing motif were identified in the 3' flanking region. Single-strand conformation polymorphism analysis was used to map mouse Ptch2 to chromosome 4 between the microsatellite markers D4Mit20 and D4Mit334.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Base Sequence -
- Chromosome Mapping -
- CpG Islands -
- DNA - genetics
- Exons - genetics
- Genome - genetics
- Humans - genetics
- Introns - genetics
- Membrane Proteins - genetics
- Mice - genetics
- Microsatellite Repeats - genetics
- Molecular Sequence Data - genetics
- Polymorphism, Single-Stranded Conformational - genetics
- Receptors, Cell Surface - genetics