Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Förstl, H; Werheid, K; Ulm, K; Schönknecht, P; Schmidt, R; Pantel, J; Hörr, R; Gutzmann, H; Gertz, HJ; Frölich, L; Bickel, H.
MCI-plus: mild cognitive impairment with rapid progression. Part II: Biomarkers and research methods
Dtsch Med Wochenschr. 2009; 134(3): 88-91.
Doi: 10.1055/s-0028-1105896
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Schmidt Reinhold
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- Abstract:
- Long-term studies will be pivotal in order to examine the efficacy of preventive and early therapeutic interventions during the preclinical phase of dementia. Biomarkers will be of importance due to the large sample sizes and the necessary logistic efforts, high drop-out rates and slow clinical progression. The validity of functional and even structural imaging methods is currently investigated with early and promising results; it is presently unclear whether conventional csf-markers of Alzheimer's disease (beta-amyloid and tau-proteins) are sufficiently sensitive to monitor the effects of early interventions. It also remains doubtful whether modifications of these methods will ever be useful and available for practical purposes.
- Find related publications in this database (using NLM MeSH Indexing)
- Alzheimer Disease - cerebrospinal fluid
- Amyloid beta-Protein - cerebrospinal fluid
- Biological Markers - cerebrospinal fluid
- Brain - pathology
- Cognition Disorders - cerebrospinal fluid
- Disease Progression - cerebrospinal fluid
- Humans - cerebrospinal fluid
- Magnetic Resonance Imaging - cerebrospinal fluid
- Magnetic Resonance Spectroscopy - cerebrospinal fluid
- Neuropsychological Tests - cerebrospinal fluid
- Positron-Emission Tomography - cerebrospinal fluid
- Tomography, Emission-Computed, Single-Photon - cerebrospinal fluid
- tau Proteins - cerebrospinal fluid
- Find related publications in this database (Keywords)
- Mild cognitive impairment
- MCI-plus
- neuropsychology
- progression
- dementia
- Alzheimer's disease
- biomarkers
- neuroimaging
- tau
- beta-amyloid