Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Resch, B; Radinger, A; Mannhalter, C; Binder, A; Haas, J; Müller, WD.
Interleukin-6 G(--174)C polymorphism is associated with mental retardation in cystic periventricular leucomalacia in preterm infants.
Arch Dis Child Fetal Neonatal Ed. 2009; 94(4): F304-F306.
Doi: 10.1136/adc.2008.140244
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Resch Bernhard
- Co-authors Med Uni Graz
- Binder Alexander
- Haas Josef
- Müller Wilhelm
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- Abstract:
- Objective: The fetal inflammatory response syndrome involving proinflammatory cytokines such as interleukin-6 (IL-6) has been associated with cystic periventricular leukomalacia (cPVL). We evaluated whether the development of cPVL is associated with the IL-6 G(-174)C polymorphism. Methods: 52 children with cPVL were compared to 46 preterm and 395 term controls using retrospective cohort analysis. IL-6 genotyping was performed using an allele specific polymerase chain reaction technique. Results: IL-6 G(-174)C polymorphisms did not differ between groups, but an association between mental retardation and the IL-6 C/C (78%) and G/C (43%) genotypes compared to the G/G (25%) genotype was found (p = 0.003 and 0.043, respectively; RR 3.11 (95% CI 1.54 to 6.29) and 1.79 (95% CI 1.10 to 2.92), respectively). Conclusions: The IL-6 (-174) C/C and G/C genotypes were associated with mental retardation in cPVL and seem to modify the severity of perinatal brain injury.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Female -
- Genetic Predisposition to Disease -
- Genotype -
- Humans -
- Infant, Newborn -
- Infant, Premature -
- Intellectual Disability - etiology
- Interleukin-6 - genetics
- Leukomalacia, Periventricular - genetics
- Male -
- Polymorphism, Genetic -
- Retrospective Studies -
- Young Adult -