Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hirt, RA; Leinker, S; Mosing, M; Wiederstein, I.
Comparison of barometric whole body plethysmography and its derived parameter enhanced pause (PENH) with conventional respiratory mechanics in healthy Beagle dogs.
Vet J. 2008; 176(2): 232-239.
Doi: 10.1016/j.tvjl.2007.05.025
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Wiederstein-Grasser Iris
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- Abstract:
- The purpose of the study was to compare barometric whole body plethysmography (BWBP) and its derived parameter, enhanced pause (PENH), with conventional respiratory mechanics measurements. Resistance (RL), dynamic compliance (Cdyn) and pleural pressure changes were measured in six healthy anaesthetised Beagle dogs using a pneumotachograph and oesophageal balloon technique consecutive to BWBP-derived variables. Upper airway airflow limitation was established (1) by a filter or (2) by insertion of a narrow endotracheal tube. Bronchoconstriction was induced by nebulisation of carbachol at increasing concentrations until PENH exceeded 300% baseline. Upper airway narrowing significantly increased resistance (baseline RL 2.0+/-0.3, RL filter 11.8+/-3.2, RL luminal narrowing 21.1+/-2.3cm H(2)O/L/s; P <0.03), whereas PENH did not change significantly (baseline PENH 0.55+/-0.17, PENH filter 0.49+/-0.10; PENH luminal narrowing 0.50+/-0.18; P >0.05). Carbachol-induced bronchoconstriction caused a significant increase in PENH (baseline PENH 0.43+/-0.14, PENH carbachol 2.62+/-2.14; P <0.02) and resistance (baseline RL 2.1+/-0.3, RL carbachol 28.8+/-13.0 cm H2O/L/s; P <0.01), and a pronounced drop in compliance (baseline Cdyn 163.3+/-73.9, Cdyn carbachol 9.7+/-2.9mL/cmH2O; P <0.02). It was concluded that BWBP detects airflow limitation due to bronchoconstriction but not due to upper airway obstruction in healthy dogs. BWBP represents a valid, although not very sensitive screening tool for respiratory function testing.
- Find related publications in this database (using NLM MeSH Indexing)
- Airway Resistance - physiology
- Animals -
- Bronchial Provocation Tests - veterinary
- Bronchoconstriction - physiology
- Carbachol - pharmacology
- Cholinergic Agonists - pharmacology
- Dogs - physiology
- Male -
- Plethysmography, Whole Body - standards Plethysmography, Whole Body - veterinary
- Reproducibility of Results -
- Respiratory Mechanics - physiology
- Find related publications in this database (Keywords)
- canine
- pulmonary function testing
- enhanced pause (PENH)
- barometric whole body plethysmography (BWBP)
- carbachol