Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mancini, L; Ciccarelli, O; Manfredonia, F; Thornton, JS; Agosta, F; Barkhof, F; Beckmann, C; De Stefano, N; Enzinger, C; Fazekas, F; Filippi, M; Gass, A; Hirsch, JG; Johansen-Berg, H; Kappos, L; Korteweg, T; Manson, SC; Marino, S; Matthews, PM; Montalban, X; Palace, J; Polman, C; Rocca, M; Ropele, S; Rovira, A; Wegner, C; Friston, K; Thompson, A; Yousry, T.
Short-term adaptation to a simple motor task: a physiological process preserved in multiple sclerosis.
Neuroimage. 2009; 45(2): 500-511.
Doi: 10.1016/j.neuroimage.2008.12.006
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- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
- Fazekas Franz
- Ropele Stefan
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- Abstract:
- Short-term adaptation indicates the attenuation of the functional MRI (fMRI) response during repeated task execution. It is considered to be a physiological process, but it is unknown whether short-term adaptation changes significantly in patients with brain disorders, such as multiple sclerosis (MS). In order to investigate short-term adaptation during a repeated right-hand tapping task in both controls and in patients with MS, we analyzed the fMRI data collected in a large cohort of controls and MS patients who were recruited into a multi-centre European fMRI study. Four fMRI runs were acquired for each of the 55 controls and 56 MS patients at baseline and 33 controls and 26 MS patients at 1-year follow-up. The externally cued (1 Hz) right hand tapping movement was limited to 3 cm amplitude by using at all sites (7 at baseline and 6 at follow-up) identically manufactured wooden frames. No significant differences in cerebral activation were found between sites. Furthermore, our results showed linear response adaptation (i.e. reduced activation) from run 1 to run 4 (over a 25 minute period) in the primary motor area (contralateral more than ipsilateral), in the supplementary motor area and in the primary sensory cortex, sensory-motor cortex and cerebellum, bilaterally. This linear activation decay was the same in both control and patient groups, did not change between baseline and 1-year follow-up and was not influenced by the modest disease progression observed over 1 year. These findings confirm that the short-term adaptation to a simple motor task is a physiological process which is preserved in MS.
- Find related publications in this database (using NLM MeSH Indexing)
- Adaptation, Physiological -
- Adult -
- Brain - physiopathology
- Brain Mapping - methods
- Evoked Potentials, Motor -
- Female -
- Hand - physiopathology
- Humans -
- Male -
- Middle Aged -
- Motor Skills -
- Movement -
- Multiple Sclerosis - physiopathology
- Task Performance and Analysis -
- Young Adult -
- Find related publications in this database (Keywords)
- fMRI
- Multiple sclerosis
- Hand movement
- Multi-centre
- Adaptation