Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Steiner, AJ; Schitter, G; Stütz, AE; Wrodnigg, TM; Tarling, CA; Withers, SG; Fantur, K; Mahuran, D; Paschke, E; Tropak, M.
1-Deoxygalactonojirimycin-lysine hybrids as potent D-galactosidase inhibitors.
Bioorg Med Chem. 2008; 16(24):10216-10220
Doi: 10.1016/j.bmc.2008.10.054
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- Co-authors Med Uni Graz
- Fantur Katrin Medea-Emma
- Paschke Eduard
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- Abstract:
- Cyclization by double reductive amination of L-arabino-hexos-5-ulose with suitably protected D- as well as L-lysine derivatives provided 1-deoxygalactonojirimycin lysine hybrids without any observable epimer formation at C-5. Modifications on the lysine moiety by acylation gave access to lipophilic derivatives which exhibited excellent D-galactosidase inhibitory activities.
- Find related publications in this database (using NLM MeSH Indexing)
- 1-Deoxynojirimycin - chemistry
- Acylation -
- Chimera -
- Enzyme Inhibitors - chemical synthesis
- Enzyme Inhibitors - metabolism
- Enzyme Inhibitors - pharmacology
- Galactosidases - antagonists & inhibitors
- Galactosidases - metabolism
- Kinetics -
- Lysine - chemistry
- Find related publications in this database (Keywords)
- Iminoalditol
- N-alkylation
- Glycosidase inhibitor
- Galactosidase inhibitor
- Iminoalditol-amino acid hybrid