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SHR Neuro Cancer Cardio Lipid Metab Microb

Tausch, C; Konstantiniuk, P; Kugler, F; Reitsamer, R; Roka, S; Poestlberger, S; Haid, A.
Sentinel Lymph Node Biopsy After Preoperative Chemotherapy for Breast Cancer: Findings from the Austrian Sentinel Node Study Group
ANNALS SURG ONCOLOGY. 2008; 15(12): 3378-3383. Doi: 10.1245/ASO.2006.08.010
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Konstantiniuk Peter
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Abstract:: Background: Sentinel lymph node biopsy (SLNB) has become an accurate alternative to axillary lymph node dissection for early breast cancer. However, data are still insufficient as regards the combination of SLNB with preoperative chemotherapy (PC). Methods: The Austrian Sentinel Node Study Group investigated 167 patients who underwent SLNB and axillary lymph node dissection after 3 to 6 courses of PC. SLNB was limited to patients with a clinically negative axilla after PC. Blue dye was used in 29 cases (17%), and tracers were used in 20 (12%). A combination of the two methods was applied in most patients (n = 120; 72%). Results: At least 1 sentinel lymph node (SLN) was identified in 144 patients (identification rate, 85%): in 86% by blue dye alone, in 65% by tracers alone, and in 88% by a combination of methods. The SLN was positive in 70 women (42%) and was the only positive node with otherwise negative axillary nodes in 39 patients (23%). In 6 cases, the SLN was diagnosed as negative although tumor infiltration was detected in an upper node of the axillary basin (false-negative rate, 8%; 6 of 76 patients; sensitivity, 92%). At least 62 patients (37%) were free of tumor cells in the SLN and in the axillary nodes. Conclusion: The results of SLNB after PC are comparable to the results of SLNB without PC. Further investigation in a prospective setting is warranted to confirm these promising results.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Antineoplastic Combined Chemotherapy Protocols -; Breast Neoplasms - diagnosis Breast Neoplasms - drug therapy Breast Neoplasms - surgery; Cyclophosphamide - administration and dosage; Doxorubicin - administration and dosage; Female -; Fluorouracil - administration and dosage; Humans -; Lymph Node Excision -; Lymphatic Metastasis -; Mastectomy -; Methotrexate - administration and dosage; Middle Aged -; Neoadjuvant Therapy -; Preoperative Care -; Retrospective Studies -; Sensitivity and Specificity -; Sentinel Lymph Node Biopsy -; Taxoids - administration and dosage
Find related publications in this database (Keywords): Sentinel biopsy; Preoperative chemotherapy; Identification rate; Sensitivity