Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Reimer, K; Hopp, M; Zenz, M; Maier, C; Holzer, P; Mikus, G; Bosse, B; Smith, K; Buschmann-Kramm, C; Leyendecker, P.
Meeting the challenges of opioid-induced constipation in chronic pain management - a novel approach.
Pharmacology. 2009; 83(1):10-17
Doi: 10.1159/000165778
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- Co-authors Med Uni Graz
- Holzer Peter
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- Abstract:
- Opioid analgesics are the cornerstone of pain management for moderate-to-severe cancer pain and, increasingly, chronic noncancer pain. Despite proven analgesic efficacy, the use of opioids is commonly associated with frequently dose-limiting constipation that seriously impacts on patients' quality of life. Agents currently used to manage opioid-induced constipation (OIC), such as laxatives, do not address the underlying opioid receptor-mediated cause of constipation and are often ineffective. A significant need therefore exists for more effective treatment options. A novel approach for selectively and locally antagonizing the gastrointestinal effects of opioids involves the coadministration of a mu-opioid receptor antagonist with negligible systemic availability, such as oral naloxone. Combination therapy with prolonged-release (PR) oxycodone plus PR naloxone has been shown to provide effective analgesia while preventing or reducing constipation. The current article highlights this novel strategy in its potential to significantly improve the quality of life of patients suffering from chronic pain, affording patients the benefit of full analgesia, without the burden of OIC.
- Find related publications in this database (using NLM MeSH Indexing)
- Analgesics, Opioid - administration & dosage
- Analgesics, Opioid - adverse effects
- Analgesics, Opioid - therapeutic use
- Chronic Disease -
- Clinical Trials as Topic -
- Constipation - chemically induced
- Constipation - prevention & control
- Dose-Response Relationship, Drug -
- Drug Therapy, Combination -
- Humans -
- Laxatives - therapeutic use
- Naloxone - therapeutic use
- Narcotic Antagonists - therapeutic use
- Oxycodone - administration & dosage
- Oxycodone - adverse effects
- Oxycodone - therapeutic use
- Pain - drug therapy
- Pain - etiology
- Quality of Life -
- Find related publications in this database (Keywords)
- Opioid
- Constipation
- Oxycodone
- Naloxone
- Analgesia