Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Haxhija, EQ; Lackner, H; Höllwarth, ME.
Medical treatment of children with hemangiomas and its limitations
Handchir Mikrochir Plast Chir. 2009; 41(2): 78-82.
Doi: 10.1055/s-2008-1038772
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Haxhija Emir
- Co-authors Med Uni Graz
- Höllwarth Michael
- Lackner Herwig
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- Abstract:
- Children with disfiguring and/or life-threatening hemangiomas need medical treatment. Initial therapy comprises the oral administration of prednisolone in a dosage between 2-3 mg/kg/day. In cases of insufficient response to prednisolone the therapy may be extended by additional subcutaneous administration of interferon-alpha in a dosage between 1-3 million U/m(2)/day. However, due to the possible serious side effects of interferon-alpha, such as irreversible spastic diplegia, this therapy must be accompanied by close and meticulous neurological examinations of the treated children. The chemotherapeutic substance vincristine has nowadays become an alternative to interferon-alpha for life-threatening hemangiomas. The substance proved effective in a dosage of 0.05 mg/kg for children less than 10 kg and 1.5 mg/kg for children more than 10 kg given weekly strictly intravenously. In worst-case scenarios, a successful disease control has been achieved by intravenous administration of cyclophosphamide in a dosage of 10 mg/kg/day given on 3 consecutive days. Medical treatment of children with life-threatening hemangiomas still remains challenging for all involved persons and should always be performed in specialised centres.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Anti-Inflammatory Agents - therapeutic use
- Antineoplastic Agents - adverse effects
- Child -
- Child, Preschool -
- Combined Modality Therapy -
- Cyclophosphamide - adverse effects
- Dose-Response Relationship, Drug -
- Drug Administration Schedule -
- Drug Therapy, Combination -
- Hemangioma - drug therapy
- Humans -
- Immunologic Factors - adverse effects
- Infant -
- Infant, Newborn -
- Infusions, Intravenous -
- Injections, Subcutaneous -
- Interferon-alpha - adverse effects
- Prednisone - adverse effects
- Skin Neoplasms - drug therapy
- Soft Tissue Neoplasms - drug therapy
- Vincristine - adverse effects
- Find related publications in this database (Keywords)
- hemangioma
- treatment
- drugs