Medizinische Universität Graz - Research portal
Selected Publication:
Deutsch, J; Fritsch, G; Gölles, J; Semmelrock, HJ.
Effects of anticonvulsive drugs on the activity of gammaglutamyltransferase and aminotransferases in serum.
J PEDIAT GASTROENTEROL NUTR. 1986; 5(4): 542-548.
Doi: 10.1097/00005176-198607000-00006
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- Leading authors Med Uni Graz
- Deutsch Johann
- Co-authors Med Uni Graz
- Semmelrock Hans-Jürgen
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- Abstract:
- A cross-sectional study was performed to define patients at risk of developing liver disease due to long-term treatment with anticonvulsive drugs. The activities of gamma-glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase and the concentrations of primidone, phenobarbital, phenytoin, and valproic acid in serum were estimated. Epileptic children before therapy were used as controls. The results indicated enzyme induction due to phenobarbital and both enzyme induction and liver cell damage or plasma membrane leakage due to phenytoin. Gamma-glutamyltransferase may be an early indicator of liver disease due to valproic acid.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Alanine Transaminase - biosynthesis
- Anticonvulsants - adverse effects
- Aspartate Aminotransferases - biosynthesis
- Child - biosynthesis
- Child, Preschool - biosynthesis
- Cross-Sectional Studies - biosynthesis
- Enzyme Induction - drug effects
- Epilepsy - drug therapy
- Humans - drug therapy
- Infant - drug therapy
- Liver - drug effects
- Phenobarbital - blood
- Phenytoin - blood
- Primidone - blood
- Risk - blood
- Time Factors - blood
- Transaminases - blood
- Valproic Acid - blood
- gamma-Glutamyltransferase - biosynthesis