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Selected Publication:
Schauenstein, K; Rossi, K; Csordas, A.
Differential inhibition of mitogen induced T cell proliferation by 5-azacytidine and cytosine-arabinoside.
Biochem Biophys Res Commun. 1988; 151(1):548-553
Doi: 10.1016/0006-291X(88)90629-8
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- Schauenstein Konrad
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- Abstract:
- The cytotoxic drugs 5-azacytidine and cytosine-arabinoside influence the enzymatic methylation of DNA in opposite ways (1,2). The in vitro effects of these two drugs on Con A induced proliferation of thymic and splenic rat lymphocytes were investigated. Cytosine-arabinoside was found to inhibit mitogen induced proliferation already at a concentration of 0.001 microM, whereas 5-azacytidine was inhibitory only above concentrations of 1 microM. A stimulation of mitogen induced T cell proliferation was consistently seen with 5-azacytidine, but not with cytosine-arabinoside, at concentrations lower than the cytotoxic concentration. The results show that 5-azacytidine and cytosine-arabinoside interfere with mitogen stimulated lymphocyte proliferation by different mechanisms and suggest that hypomethylated DNA plays a role in the proliferation of T cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Azacitidine - pharmacology
- Concanavalin A - pharmacology
- Cytarabine - pharmacology
- DNA - metabolism
- Gene Expression Regulation - metabolism
- Lymphocyte Activation - drug effects
- Male - drug effects
- Methylation - drug effects
- Rats - drug effects
- Rats, Inbred Strains - drug effects
- Spleen - cytology
- T-Lymphocytes - drug effects
- Thymus Gland - cytology