Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Werner, B; Massone, C; Kerl, H; Cerroni, L.
Large CD30-positive cells in benign, atypical lymphoid infiltrates of the skin.
J CUTANEOUS PATHOL. 2008; 35(12): 1100-1107.
Doi: 10.1111/j.1600-0560.2007.00979.x
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- Führende Autor*innen der Med Uni Graz
- Cerroni Lorenzo
- Co-Autor*innen der Med Uni Graz
- Kerl Helmut
- Massone Cesare
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- Abstract:
- Background: Cutaneous infectious and inflammatory diseases may contain a significant number of CD30-positive cells, thus mimicking lymphomatoid papulosis (LyP) or anaplastic large cell lymphoma. Methods: We reviewed our cases of non-neoplastic skin conditions with large, CD30-positive cells and searched the literature for similar cases. Results: A total of 28 cases were included in the study: Milker's nodule (n = 8), Herpes simplex virus infection (n = 7), lymphomatoid drug reaction (n = 3), molluscum contagiosum (n = 3), nodular scabies (n = 2), leishmaniasis (n = 1), syphilis (n = 1), pernio (n = 1), ruptured infundibular cyst (n = 1) and pseudolymphoma in a scar (n = 1). CD30-positive cells were often arranged in clusters and revealed both Golgi and membrane positivity, similar to what was observed in LyP and CD30+ anaplastic large T-cell lymphoma. Conclusions: Analysis of our data and of those published in the literature shows that viruses and drugs are the most common cause for occurrence of large CD30-positive cells in cutaneous pseudolymphomatous infiltrates. Arrangement of these large, CD30-positive cells in small clusters is not unique to cutaneous CD30-positive lymphomas, and in many cases a precise diagnosis can be made only upon accurate clinicopathological correlation or using ancillary methods such as polymerase chain reaction analysis for viral DNA.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Antigens, CD30 - metabolism
- Child -
- Child, Preschool -
- Diagnosis, Differential -
- Drug Toxicity - metabolism
- Female -
- Humans -
- Infant -
- Lymphoma, Large-Cell, Anaplastic - pathology
- Lymphomatoid Papulosis - pathology
- Male -
- Middle Aged -
- Skin Diseases - etiology
- Skin Neoplasms - pathology
- Virus Diseases - metabolism