Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schneuber, SE; Scholz, HS; Regitnig, P; Petru, E; Winter, R.
Breast metastasis 56 months before the diagnosis of primary ovarian cancer: a case study.
ANTICANCER RES. 2008; 28(5B): 3047-3050.
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Schneuber Susanne
- Co-Autor*innen der Med Uni Graz
- Petru Edgar
- Regitnig Peter
- Scholz Heinz
- Winter Raimund
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- Abstract:
- BACKGROUND: Breast metastasis of ovarian cancer is rare. A patient with a breast tumor which turned out to be a metastasis as the first clinical manifestation of a primary ovarian cancer diagnosed 56 months later is described. CASE REPORT: A 72-year-old patient presented with a palpable mass in the right breast. Lumpectomy was performed and primary breast cancer was excluded. Histology confirmed a poorly differentiated adenocarcinoma. However, further examination showed no evidence of extramammary primary malignancy. Fifty-six months later, a multicystic pelvic lesion with irregular septa was found. Laparotomy showed a tumor of the right adnexa. The final pathology confirmed the diagnosis of a primary serous ovarian carcinoma. The paraffin blocks of both tumors were reevaluated and showed that the cytological atypia and the immunohistochemical profiles [cytokeratin (CK) 5/6, CK 17, gross cystic disease fluid protein (GCDFP)-15 / BRST-2, estrogen- and progesterone receptor, cancer antigen (CA)125, Wilms tumor (WT-1), tumorsuppressor gene p53, MIB-1 (proliferation marker)] were similar in both the breast and the ovarian specimens. CONCLUSION: To our knowledge, this is the first report of a breast metastasis preceding the diagnosis of primary ovarian cancer by several years.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Breast Neoplasms - secondary
- Female - secondary
- Humans - secondary
- Ovarian Neoplasms - diagnosis
- Find related publications in this database (Keywords)
- Breast metastasis
- primary ovarian cancer
- diagnosis