Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Gouw, AA; van der Flier, WM; Pantoni, L; Inzitari, D; Erkinjuntti, T; Wahlund, LO; Waldemar, G; Schmidt, R; Fazekas, F; Scheltens, P; Barkhof, F.
On the etiology of incident brain lacunes: longitudinal observations from the LADIS study.
Stroke. 2008; 39(11):3083-3085
Doi: 10.1161/STROKEAHA.108.521807
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-authors Med Uni Graz
- Fazekas Franz
- Schmidt Reinhold
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND AND PURPOSE: We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period. METHODS: Baseline and 3-year follow-up MRI were collected within the LADIS study (n=358). Incident lacunes were characterized with respect to brain region, their appearance within pre-existent white matter hyperintensities (WMH), surrounding WMH size, and risk factors. RESULTS: 106 incident lacunes were observed in 62 patients (58 subcortical white matter [WM], 35 basal ganglia, and 13 infratentorial). Incident subcortical WM lacunes occurred more often within preexisting WMH (P=0.01) and were mostly accompanied by new and expanded WMH (P<0.001), compared to incident basal ganglia and infratentorial lacunes. Risk factors for incident subcortical WM lacunes were history of hypertension and stroke, whereas atrial fibrillation predicted incident basal ganglia/infratentorial lacunes. CONCLUSIONS: Differences in relation to WMH and risk factor profiles may suggest that incident lacunes in the subcortical WM have a different pathogenesis than those in the basal ganglia and infratentorial region.
- Find related publications in this database (using NLM MeSH Indexing)
- Basal Ganglia - pathology
- Brain Infarction - etiology
- Humans - etiology
- Leukoaraiosis - pathology
- Longitudinal Studies - pathology
- Magnetic Resonance Imaging - pathology
- Nerve Fibers, Myelinated - pathology
- Risk Factors - pathology
- Find related publications in this database (Keywords)
- lacunes
- white matter hyperintensities
- MRI