Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Li, ZX; Sturm, S; Svejda, B; Hoger, H; Schraml, E; Ingolic, E; Siegl, V; Stuppner, H; Pfragner, R.
Anticancer Activity of Novel Extracts from Cautleya gracilis (Smith) Dandy: Apoptosis in Human Medullary Thyroid Carcinoma Cells
ANTICANCER RES. 2008; 28(5A): 2705-2713.
Web of Science
- Leading authors Med Uni Graz
- Pfragner Roswitha
- Co-authors Med Uni Graz
- Siegl Veronika
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- Abstract:
- Background: Medullary thyroid carcinoma (MTC) is a calcitonin-producing tumor of the thyroid arising from the parafollicular C-cells. MTC is poorly responsive to chemotherapy and radiotherapy, hence the only effective therapy is surgery. Based on this fact, alternative strategies have been sought. Materials and Methods: The effects of Cautleya gracilis (Smith) Dandy were investigated for the first time in three human MTC cell lines and in MTC-transplanted mice. Proliferation and viability were quantified by cell counting, WST-1 tests, and ATP luminescent cell viability assays. Apoptosis was studied by DAPI staining, flow cytometry and luminescent assays for caspases 317, 8 and 9. Results: A dose-dependent reduction of proliferation and an induction of apoptosis were found in all MTC cell lines, while normal fibroblasts were not impaired. Similar tumor inhibition was seen in heterotransplanted mice. Conclusion: Our in vitro and in vivo findings suggest a new potential clinical effect of Cautleya.
- Find related publications in this database (Keywords)
- Cautleya gracilis
- bioactive agents
- medullary thyroid carcinoma
- chemoresistance
- apoptosis