Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Smolle, J; Soyer, HP; Ehall, R; Stettner, H; Kerl, H.
NK cell density in malignant skin tumours--a stereological study.
BRIT J DERMATOL 1987 116: 823-829.
Doi: 10.1111/j.1365-2133.1987.tb04901.x
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- Führende Autor*innen der Med Uni Graz
- Smolle Josef
- Co-Autor*innen der Med Uni Graz
- Kerl Helmut
- Soyer Hans Peter
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- Abstract:
- We determined the density of natural killer (NK) cells in frozen sections of malignant melanoma (nine cases), squamous cell carcinoma (six cases) and non-neoplastic tonsil (five cases) by immunohistological and stereological methods. The mean density of NK cells in malignant melanoma (5.0 +/- 1.5 X 10(3)/mm3) and in squamous cell carcinoma (5.1 +/- 2.7 X 10(3)/mm3) was significantly lower than in germinal centres of normal human tonsils (5.0 +/- 0.8 X 10(4)/mm3). The NK cell/tumour cell ratio (0.03 +/- 0.015 in malignant melanoma and 0.02 +/- 0.015 in squamous cell carcinoma) is 10(2)-10(4) times lower than that commonly used for in vitro assays. The possible role of NK cells in malignant skin tumours should be viewed with caution.
- Find related publications in this database (using NLM MeSH Indexing)
- Biopsy -
- Carcinoma, Squamous Cell - immunology
- Cell Count - immunology
- Humans - immunology
- Killer Cells, Natural - immunology
- Melanoma - immunology
- Research Support, Non-U.S. Gov't - immunology
- Skin - pathology
- Skin Neoplasms - immunology
- Tonsil - pathology