Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Muradyan, A; Boldt, V; Steininger, A; Stabentheiner, S; Tebel, K; Kreutzberger, J; Muller, I; Madle, H; Popper, HH; Ullmann, R.
An Integrative Approach for Analyzing the Interplay of Genetic and Epigenetic Changes in Tumors
ARCH PATHOL LAB MED. 2008; 132(10): 1557-1561.
Doi: 10.5858/2008-132-1557-AIAFAT
[Oral Communication]
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- Co-Autor*innen der Med Uni Graz
- Popper Helmuth
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- Abstract:
- The accumulation of chromosomal aberrations is a characteristic feature of tumor development. However, an understanding of tumorigenesis that assumes that changes in DNA copy number always cause equivalent changes in the corresponding RNA and protein levels is an oversimplification and completely ignores the individual genetic and epigenetic context in which an aberration has to be evaluated. We present a brief introduction to various techniques dedicated to the genome-wide analysis of genetic and epigenetic changes, and illustrate how complementary information derived from these various DNA array-based technologies can lead to a better understanding of the consequences of chromosomal aberrations. (Arch Pathol Lab Med. 2008; 132: 1557 - 1561)