Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lackner, H; Sovinz, P; Benesch, M; Smolle-Jüttner, F; Mokry, M; Schwinger, W; Moser, A; Urban, C.
Management of brain abscesses in children treated for acute lymphoblastic leukemia.
Pediatr Blood Cancer. 2009; 52(3): 408-411.
Doi: 10.1002/pbc.21814
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Lackner Herwig
- Co-Autor*innen der Med Uni Graz
- Benesch Martin
- Mokry Michael
- Nebl Andrea Maria
- Ritter-Sovinz Petra
- Schwinger Wolfgang
- Smolle-Juettner Freyja-Maria
- Urban Ernst-Christian
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- Abstract:
- Brain abscesses in children with leukemia or other malignancies are rare and potentially fatal. We report on four children who developed brain abscesses during treatment for acute lymphoblastic leukemia (ALL). All patients received multimodal broad-spectrum antibiotic therapy and liposomal amphotericin-B in combination with hyperbaric oxygen. First-line antimicrobial treatment was modified when a causative organism was isolated. All four patients survived, with two patients showing complete resolution of neurological and MRI abnormalities and with two patients still having residual lesions. To date, all patients are in remission with three patients still receiving antileukemic therapy. Brain abscesses can be successfully managed by a multimodality approach even in severely immunocompromised cancer patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Anti-Bacterial Agents - therapeutic use
- Antineoplastic Agents - therapeutic use
- Brain Abscess - complications Brain Abscess - drug therapy
- Child, Preschool -
- Female -
- Humans -
- Infant, Newborn -
- Male -
- Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
- Find related publications in this database (Keywords)
- acute lymphoblastic leukemia
- brain abscesses
- children
- management