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SHR Neuro Cancer Cardio Lipid Metab Microb
van Maldegem, F; van Dijk, R; Wormhoudt, TA; Kluin, PM; Willemze, R; Cerroni, L; van Noesel, CJ; Bende, RJ.
The majority of cutaneous marginal zone B-cell lymphomas expresses class-switched immunoglobulins and develops in a T-helper type 2 inflammatory environment.
Blood. 2008; 112(8):3355-3361
Doi: 10.1182/blood-2008-01-132415
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- Co-authors Med Uni Graz
- Cerroni Lorenzo
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- Abstract:
- Extranodal marginal zone B-cell lymphomas (MZBCLs) arise on a background of chronic inflammation resulting from organ-specific autoimmunity, infection, or by unknown causes. Well-known examples are salivary gland MZBCL in Sjögren's sialadenitis and gastric MZBCL in Helicobacter pylori gastritis. MZBCLs express CXCR3, a receptor for interferon-gamma-induced chemokines highly expressed in the chronic inflammatory environment. The immunoglobulin (Ig) variable heavy/light chain (IgV(H)/IgV(L)) gene repertoire of salivary gland and gastric MZBCL appears restricted and frequently encodes B-cell receptors with rheumatoid factor reactivity. Primary cutaneous marginal zone B-cell lymphomas (PCMZLs) are regarded as the skin-involving counterparts of extranodal MZBCLs. Although PCMZLs have been associated with Borrelia burgdorferi dermatitis, PCMZLs generally arise because of unknown causes. We studied an extensive panel of PCMZLs and show that PCMZLs do not conform to the general profile of extranodal MZBCL. Whereas most noncutaneous MZBCLs express IgM, PCMZLs in majority express IgG, IgA, and IgE and do not show an obvious immunoglobulin repertoire bias. Furthermore, the isotype-switched PCMZLs lack CXCR3 and seem to arise in a different inflammatory environment, compared with other extranodal MZBCLs.
- Find related publications in this database (using NLM MeSH Indexing)
- Antigens, CD20 - biosynthesis
- Complementarity Determining Regions - metabolism
- Humans -
- Immunoglobulin A - chemistry
- Immunoglobulin Class Switching -
- Immunoglobulin E - chemistry
- Immunoglobulin G - chemistry
- Immunoglobulins - metabolism
- Inflammation -
- Interferon-gamma - metabolism
- Lymphoma, B-Cell, Marginal Zone - immunology
- Lymphoma, B-Cell, Marginal Zone - metabolism
- Lymphoma, B-Cell, Marginal Zone - pathology
- Models, Biological -
- Receptors, CXCR3 - metabolism
- Rheumatoid Factor - metabolism
- Th2 Cells - metabolism