Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hochmeister, S; Zeitelhofer, M; Bauer, J; Nicolussi, EM; Fischer, MT; Heinke, B; Selzer, E; Lassmann, H; Bradl, M.
After injection into the striatum, in vitro-differentiated microglia- and bone marrow-derived dendritic cells can leave the central nervous system via the blood stream.
Am J Pathol. 2008; 173(6): 1669-1681.
Doi: 10.2353/ajpath.2008.080234
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- Führende Autor*innen der Med Uni Graz
- Hochmeister Sonja
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- Abstract:
- The prototypic migratory trail of tissue-resident dendritic cells (DCs) is via lymphatic drainage. Since the central nervous system (CNS) lacks classical lymphatic vessels, and antigens and cells injected into both the CNS and cerebrospinal fluid have been found in deep cervical lymph nodes, it was thought that CNS-derived DCs exclusively used the cerebrospinal fluid pathway to exit from tissues. It has become evident, however, that DCs found in peripheral organs can also leave tissues via the blood stream. To study whether DCs derived from microglia and bone marrow can also use this route of emigration from the CNS, we performed a series of experiments in which we injected genetically labeled DCs into the striata of rats. We show here that these cells migrated from the injection site to the perivascular space, integrated into the endothelial lining of the CNS vasculature, and were then present in the lumen of CNS blood vessels days after the injection. Moreover, we also found these cells in both mesenteric lymph nodes and spleens. Hence, microglia- and bone marrow-derived DCs can leave the CNS via the blood stream.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Biological Markers - metabolism
- Bone Marrow Cells - cytology
- Cell Differentiation - physiology
- Cell Lineage -
- Cell Movement - physiology
- Cells, Cultured -
- Central Nervous System - anatomy and histology
- Dendritic Cells - cytology
- Injections -
- Lymph Nodes - cytology
- Microglia - cytology
- Oligonucleotide Array Sequence Analysis -
- Radiation Chimera -
- Rats -
- Rats, Inbred Lew -
- Rats, Sprague-Dawley -
- Rats, Transgenic -
- Spleen - cytology
- T-Lymphocytes - cytology