Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Vrecko, K; Schwingenschuh, P; Holl, A; Saurugg, R; Wenzel, K; Katschnig, P; Tafeit, E; Ott, E.
Immunological markers in plasma and CSF distinguish vascular parkinsonism from idiopathic Parkinson's disease
PTERIDINES. 2008; 19(1): 7-11.
Doi: 10.1515/pteridines.2008.19.1.7
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Vrecko Karoline
- Co-Autor*innen der Med Uni Graz
- Holl Alexander
- Katschnig-Winter Petra
- Ott Erwin
- Saurugg Ronald
- Schwingenschuh Petra
- Tafeit Erwin
- Wenzel Karoline
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- Abstract:
- Activation of the cellular immune system is discussed to be partly responsible in the neurodegenerative process of Parkinson's disease. We determined concentrations of neopterin, of cytokine interleukin-6, and of soluble cytokine receptors sIL-2R alpha, sTNF-R75 alpha in plasma and cerebrospinal fluid in controls and patients with vascular parkinsonism and idiopathic Parkinson's disease diagnosed according to published clinical diagnostic criteria, to examine if the cellular immune system is activated locally or peripherally or both. Our results show no activation in idiopathic Parkinson's disease and controls, but a significant increased activation in vascular parkinsonism, where concomitant signs of cerebrovascular disease are present.
- Find related publications in this database (Keywords)
- idiopathic Parkinson's disease
- vascular parkinsonism
- neopterin
- interleukin-6
- sIL-2R alpha
- sTNF-R75 alpha