Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Benesch, M; Spiegl, K; Winter, A; Passini, A; Lackner, H; Moser, A; Sovinz, P; Schwinger, W; Urban, C.
A scoring system to quantify late effects in children after treatment for medulloblastoma/ependymoma and its correlation with quality of life and neurocognitive functioning.
Childs Nerv Syst. 2009; 25(2): 173-181.
Doi: 10.1007/s00381-008-0742-1
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- Führende Autor*innen der Med Uni Graz
- Benesch Martin
- Co-Autor*innen der Med Uni Graz
- Lackner Herwig
- Nebl Andrea Maria
- Ritter-Sovinz Petra
- Schwinger Wolfgang
- Urban Ernst-Christian
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- Abstract:
- BACKGROUND: The aim of this study was to quantify the severity of late effects by a simple numerical score (late effects severity score, LESS) in patients who received radiochemotherapy for medulloblastoma or ependymoma. The LESS was correlated with neurocognitive and quality of life (QoL) outcomes. PATIENTS AND METHODS: The LESS was calculated by assigning 0, 1, or 2 points within each of four different categories (neurology, endocrine, visual/auditory, others). Twenty-three patients with medulloblastoma (n = 18) or ependymoma (n = 5) underwent extensive neurocognitive and QoL testing at a median of 56 months (range, 1-174) after the end of treatment. Eight patients with low-grade glioma (LGG) who underwent tumor resection only served as control group. RESULTS: Patients with medulloblastoma/ependymoma had significantly higher LESS and significantly lower Wechsler Adult Intelligence Scale (WAIS)/Wechsler Intelligence Scales for Children (WISC) scores compared to patients with LGG. There was no statistically significant correlation between neurocognitive performance and QoL. The total LESS was negatively correlated with WAIS/WISC, attention, concentration, and verbal learning scores. Comparison of QoL and late effects in patients with medulloblastoma/ependymoma demonstrated a significant negative correlation only for neurological late effects and the KINDL score suggesting that younger patients with more severe late effects reported on a worse QoL. CONCLUSIONS: This LESS seems to be a simple and practical tool to quantify late effects in former brain tumor patients. Although both groups differ significantly with regard to neurocognitive parameters and severity of late effects, this does not apply for all QoL outcomes. Neurological late effects seem to be most predictive for an impaired QoL in younger children.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Child -
- Child, Preschool -
- Cognition - drug effects Cognition - physiology Cognition - radiation effects
- Combined Modality Therapy - adverse effects
- Drug Therapy - adverse effects
- Endocrine System - drug effects Endocrine System - physiopathology Endocrine System - radiation effects
- Ependymoma - pathology Ependymoma - therapy
- Female -
- Follow-Up Studies -
- Hearing - drug effects Hearing - physiology Hearing - radiation effects
- Humans -
- Infant -
- Magnetic Resonance Imaging - methods
- Male -
- Medulloblastoma - pathology Medulloblastoma - therapy
- Nervous System Diseases - etiology Nervous System Diseases - physiopathology
- Outcome Assessment (Health Care) - methods
- Quality of Life -
- Radiotherapy - adverse effects
- Time Factors -
- Verbal Learning - drug effects Verbal Learning - physiology Verbal Learning - radiation effects
- Vision, Ocular - drug effects Vision, Ocular - physiology Vision, Ocular - radiation effects
- Young Adult -
- Find related publications in this database (Keywords)
- Children
- Primitive neuroectodermal tumors
- Low-grade astrocytoma
- Late effects
- Quality of life
- Neurocognitive functioning