Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Boogaerts, M; Coiffier, B; Kainz, C; Epoetin beta QOL Working Group.
Impact of epoetin beta on quality of life in patients with malignant disease.
Br J Cancer. 2003; 88(7):988-995 Doi: 10.1038/sj.bjc.6600801 [OPEN ACCESS]
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Study Group Mitglieder der Med Uni Graz:: Richtig Erika
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Abstract:: This open-label, prospective study was conducted to compare the impact of epoetin beta vs standard care on quality of life (QoL) in anaemic patients with lymphoid or solid tumour malignancies. A total of 262 anaemic patients (haemoglobin [Hb]or=2 g dl(-1) increase in Hb level without need of transfusion after the initial 4 weeks of treatment. Baseline to final visit changes in SF-36 PCS, FACT-F and VAS scores were significantly greater with epoetin beta than with standard care (P<0.05); changes in FACT-An subscale score tended to be greater with epoetin beta (P=0.076). Epoetin beta significantly increased Hb concentrations relative to standard care (responders: 47% vs 13%; P<0.001). Levels of endogenous erythropoietin <50 mIU ml(-1) were significantly predictive of response (OR 2.496, 95% CI: 1.21-5.13). Epoetin beta therapy significantly improves QoL compared with standard care in anaemic patients with solid tumours and lymphoid malignancies.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Aged, 80 and over -; Erythropoietin - adverse effects; Erythropoietin, Recombinant - adverse effects; Female - adverse effects; Humans - adverse effects; Male - adverse effects; Middle Aged - adverse effects; Neoplasms - drug therapy; Prospective Studies - drug therapy; Quality of Life - drug therapy
Find related publications in this database (Keywords): erythropoietin; recombinant; quality of life; neoplasms; anaemia; factors; predisposing