Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Wallner, SJ; Horejsi, R; Zweiker, R; Watzinger, N; Möller, R; Schnedl, WJ; Schauenstein, K; Tafeit, E.
ROC analysis of subcutaneous adipose tissue topography (SAT-Top) in female coronary heart disease patients and healthy controls.
J Physiol Anthropol. 2008; 27(4):185-191
Doi: 10.2114/jpa2.27.185
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- Leading authors Med Uni Graz
- Holasek Sandra Johanna
- Co-authors Med Uni Graz
- Horejsi Renate
- Möller Reinhard
- Schauenstein Konrad
- Schnedl Wolfgang
- Tafeit Erwin
- Watzinger Norbert
- Zweiker Robert
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- Abstract:
- The aim of this study was to investigate whether subcutaneous adipose tissue topography (SAT-Top) is different in female CHD patients (n=26) and healthy controls (n=36) matched to age, body size, weight, and BMI. The thicknesses of SAT layers were measured by LIPOMETER at 15 specified body sites. To calculate the power of the different body sites to discriminate between CHD women and healthy controls, receiver operating characteristic (ROC) curve analysis was performed. For each parameter, sensitivity and specificity were calculated at different cutoff points. CHD women showed a significant decrease to 78.36% (p=0.012) at body site 11-front thigh, 73.10% (p=0.012) at 12-lateral thigh, 72.20% (p=0.009) at 13-rear thigh, 66.43% (p<0.001) at 14-inner thigh, and 49.19% (p<0.001) at 15-calf. The best discriminators analysed by ROC curves between female CHD patients and healthy controls turned out to be calf and inner thigh (optimal cut off values: calf: 3.85 mm and inner thigh: 11.15 mm). Stepwise discriminant analysis identified the body sites calf, lateral chest, and inner thigh as significant. In conclusion, information was obtained on the extent to which SAT thickness at each measured body site is able to discriminate between the two subject groups. The good discrimination results obtained for the present dataset are encouraging enough to recommend applying LIPOMETER SAT-Top measurements in further studies to investigate individual risks for CHD.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Body Composition -
- Body Fat Distribution -
- Case-Control Studies -
- Coronary Artery Disease - metabolism
- Female -
- Humans -
- Middle Aged -
- ROC Curve -
- Subcutaneous Fat - anatomy & histology