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SHR Neuro Cancer Cardio Lipid Metab Microb

Basset-Seguin, N; Ibbotson, SH; Emtestam, L; Tarstedt, M; Morton, C; Maroti, M; Calzavara-Pinton, P; Varma, S; Roelandts, R; Wolf, P.
Topical methyl aminolaevulinate photodynamic therapy versus cryotherapy for superficial basal cell carcinoma: a 5 year randomized trial.
Eur J Dermatol. 2008; 18(5): 547-553. Doi: 10.1684/ejd.2008.0472 [OPEN ACCESS]
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Co-authors Med Uni Graz: Wolf Peter
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Abstract:: This multicentre, randomized study compared photodynamic therapy using topical methyl aminolaevulinate (MAL PDT), a non-invasive modality, with cryotherapy for treatment of superficial basal cell carcinoma. Sixty patients with 114 lesions were treated with MAL cream (160 mg/g) applied for 3 hours before illumination (570-670 nm, light dose 75 J/cm) (1 session), and 58 with 105 lesions received cryotherapy (2 freeze-thaw cycles). Patients with an incomplete response at 3 months received 2 further MAL PDT sessions (n = 20) or repeat cryotherapy (n = 16). 100 lesions treated with MAL PDT and 93 lesions treated with cryotherapy were in complete response at 3 months after the last treatment and evaluable for recurrence over 5 years. There was no difference in 5-year recurrence rates with either treatment (20% with cryotherapy vs. 22% with MAL PDT, p = 0.86). However, more patients had an excellent cosmetic outcome with MAL PDT (60% vs. 16% with cryotherapy, p = 0.00078). These results provide support for the use of MAL PDT as a non-invasive, selective treatment alternative for primary superficial basal cell carcinoma.
Find related publications in this database (using NLM MeSH Indexing): Administration, Topical -; Adult -; Aged -; Aged, 80 and over -; Aminolevulinic Acid - administration and dosage; Carcinoma, Basal Cell - pathology; Cryotherapy -; Female -; Humans -; Male -; Middle Aged -; Photochemotherapy -; Photosensitizing Agents - administration and dosage; Skin Neoplasms - pathology; Time Factors -
Find related publications in this database (Keywords): methyl aminolaevulinate; photodynamic therapy; superficial basal cell carcinoma