Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gerger, A; Hofmann, G; Langsenlehner, U; Renner, W; Weitzer, W; Wehrschütz, M; Wascher, T; Samonigg, H; Krippl, P.
Integrin alpha-2 and beta-3 gene polymorphisms and colorectal cancer risk.
Int J Colorectal Dis. 2009; 24(2):159-163
Doi: 10.1007/s00384-008-0587-9
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- Führende Autor*innen der Med Uni Graz
- Gerger Armin
- Hofmann Guenter
- Co-Autor*innen der Med Uni Graz
- Langsenlehner Uwe
- Renner Wilfried
- Samonigg Hellmut
- Wehrschütz Martin
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- Abstract:
- Integrins such as alpha(2)beta(1), alpha(IIb)beta(3), and alpha(v)beta(3) have been suggested as key players for cancer development and progression. Several polymorphisms affecting these molecules, two in integrin alpha(2) (ITGA2 807C > T and 1648G > A) and one in beta(3) (ITGB3 176T > C), influence their levels, structure, and possibly their function. To analyze the role of ITGA2 and ITGB3 polymorphisms for colorectal cancer risk and clinical presentation, we performed a case-control study. Four hundred thirty-three colorectal cancer patients and 433 healthy sex- and age-matched control subjects were investigated. ITGA2 and ITGB3 polymorphisms were determined by 5'-nuclease assays. The ITGA2 807C > T polymorphism was associated with reduced colorectal cancer risk. In a codominant model, the odds ratio for each additional 807-T allele for colorectal cancer was 0.77 (95% confidence interval 0.64-0.94; p = 0.011). The ITGA2 1648G > and the ITGB3 176T > C polymorphism were not associated with colorectal cancer. None of the three polymorphisms investigated was associated with tumor size, histological grade, presence of primary lymph node metastases, tumor stage, or age at diagnosis. We conclude that the ITGA2 807C > T polymorphism may be associated with reduced colorectal cancer risk.
- Find related publications in this database (using NLM MeSH Indexing)
- Case-Control Studies -
- Colorectal Neoplasms - genetics
- Demography -
- Female -
- Genetic Predisposition to Disease -
- Humans -
- Integrin alpha2 - genetics
- Integrin beta3 - genetics
- Male -
- Middle Aged -
- Polymorphism, Single Nucleotide - genetics
- Find related publications in this database (Keywords)
- Epidemiology
- Prevention
- Genetics
- Integrins
- Colorectal cancer