Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Smolle, J; Ehall, R; Kerl, H.
Inflammatory cell types in normal human epidermis--an immunohistochemical and morphometric study.
Acta Derm Venereol. 1985; 65(6):479-483
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- Führende Autor*innen der Med Uni Graz
- Smolle Josef
- Co-Autor*innen der Med Uni Graz
- Kerl Helmut
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- Abstract:
- Inflammatory cells in 15 specimens of normal human epidermis were selectively stained by a monoclonal antibody immunoperoxidase technique. The quantitative assessment using an interactive image analysis system revealed OKT 11 positive cells (T lymphocytes) and Leu 2a positive cells (suppressor/cytotoxic cells). As there was no significant difference in the distribution of these markers, helper/inducer cells obviously are not present in considerable amounts. OKM 5 positive cells outnumbered OKM 1 positive cells, indicating the presence of a OKM 5+, OKM 1-macrophage subset. The epidermal dendritic cells clearly showed a striking heterogeneity regarding the expression of HLA-DR (62% of OKT 6-positive cells) and Leu 3a (47%), suggesting the existence of immunologically distinct subsets of human epidermal dendritic cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Antibodies, Monoclonal -
- Epidermis - pathology
- Histocytochemistry - pathology
- Humans - pathology
- Immunoenzyme Techniques - pathology
- Indicators and Reagents - pathology
- Inflammation - pathology
- Langerhans Cells - pathology
- Macrophages - pathology
- T-Lymphocytes - pathology