Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bensalah, K; Pantuck, AJ; Crepel, M; Verhoest, G; Méjean, A; Valéri, A; Ficarra, V; Pfister, C; Ferrière, JM; Soulié, M; Cindolo, L; De La Taille, A; Tostain, J; Chautard, D; Schips, L; Zigeuner, R; Abbou, CC; Lobel, B; Salomon, L; Lechevallier, E; Descotes, JL; Guillé, F; Colombel, M; Belldegrun, AS; Patard, JJ.
Prognostic variables to predict cancer-related death in incidental renal tumours.
BJU Int. 2008; 102(10): 1376-1380.
Doi: 10.1111/j.1464-410X.2008.07847.x
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- Co-Autor*innen der Med Uni Graz
- Zigeuner Richard
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- Abstract:
- OBJECTIVE: To identify, in a large multicentre series of incidental renal tumours, the key factors that could predict cancer-related deaths, as such tumours have a better outcome than symptomatic tumours and selected patients are increasingly being included in watchful-waiting protocols. PATIENTS AND METHODS: Data from 3912 patients were extracted from three international kidney-cancer databases. Age, gender, Eastern Cooperative Oncology Group (ECOG) performance status (PS), Tumour-Node-Metastasis (TNM) stage, tumour size, Fuhrman grade, and final pathology were recorded. Benign tumours and malignant lesions with incomplete information were excluded from final analysis. RESULTS: The mean (SD) age of the patients was 60.6 (12.2) years and the mean tumour size 5.5 (3.5) cm. Most tumours were malignant (90.2%) and of low stage (T1-T2, 71.7%) and low grade (G1-G2, 72.4%). There were nodal and distant metastases in 5.7% and 13% of the patients. In all, 525 (14.4%) patients died from cancer; in this group, tumours were >4 cm in 88.2% and had nodal or distant metastases in 20.2% and 49.3%, respectively. Multivariable analysis showed that tumour size >4 cm, ECOG PS >or=1, TNM stage and Fuhrman grade were independent predictors of cancer-related death. CONCLUSION: A significant proportion of incidental renal tumours can lead to the death of the patient. Standard prognostic variables for renal cell carcinoma appear to remain valid for this subset of patients. A watchful-waiting strategy should not be recommended if the tumour diameter is >4 cm, if biopsy confirms high-grade tumours, or if there is an impaired ECOG PS, or computed tomography findings suggest the presence of advanced T stage.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma, Renal Cell - mortality
- Female -
- Humans -
- Incidental Findings -
- Kidney Neoplasms - mortality
- Male -
- Middle Aged -
- Multivariate Analysis -
- Neoplasm Staging -
- Nephrectomy - methods
- Prognosis -
- Retrospective Studies -
- Survival Analysis -
- Young Adult -
- Find related publications in this database (Keywords)
- incidental tumour
- renal cell carcinoma
- watchful waiting
- prediction