Medizinische Universität Graz - Research portal
Selected Publication:
Cvirn, G; Gallistl, S; Muntean, W.
Effects of antithrombin and protein C on thrombin generation in newborn and adult plasma.
Thromb Res. 1999; 93(4):183-190
Doi: 10.1016%2FS0049-3848%2898%2900181-9
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- Leading authors Med Uni Graz
- Cvirn Gerhard
- Co-authors Med Uni Graz
- Gallistl Siegfried
- Muntean Eugen
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- Abstract:
- It has been suggested that antithrombin (AT) and protein C (PC) might be less important in newborn plasma than in adult plasma for the inhibition of clotting activation. To assess the importance of AT and PC for the regulation of thrombin generation in newborn as compared with adult plasma, thrombin generation was determined in the presence of different concentrations of AT and PC. In both, newborn and adult plasmas, reduction of AT and PC resulted in an increase of thrombin generation after intrinsic activation. On the other hand, supplementation of AT and PC decreased thrombin generation in a dose-dependent manner. Clotting times were influenced by different PC concentrations, whereas clotting times were almost not affected by different amounts of AT. Our study suggests that the significance of AT and PC in the regulation of thrombin generation is the same in newborn and adult plasma. Our experimental results also support the notion that administration of AT or protein C concentrates may be beneficial in some clinical situations leading to an increased clotting activation in newborns.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age Factors -
- Antithrombins - pharmacology
- Blood Coagulation - pharmacology
- Dose-Response Relationship, Drug - pharmacology
- Fetal Blood - pharmacology
- Humans - pharmacology
- Infant, Newborn - pharmacology
- Protein C - pharmacology
- Thrombin - metabolism
- Find related publications in this database (Keywords)
- Thrombin Generation
- Protein C
- Antithrombin
- Antithrombotic Regulatory Systems