Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Popper, H; Jakse, R; Loidolt, D.
Problems in the differential diagnosis of Kartagener's syndrome and ATP-ase deficiency.
PATHOL RES PRACT. 1985; 180: 481-485.
Doi: 10.1016/S0344-0338(85)80008-X
(- Case Report)
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Popper Helmuth
- Co-Autor*innen der Med Uni Graz
- Lang-Loidolt Doris
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- Abstract:
- Two cases of Kartagener's syndrome with a partial loss of the dynein arms and the central spokes within the cilia are presented. In light microscopic examination the predominant cell types were mast cells within the stroma and the epithelium and plasma cells and lymphocytes in the stroma. The reaction for the magnesium-activated ATP-ase located in the apical cytoplasm of ciliated cells was negative in one case and slightly positive in the same case on year later; in our second case, the ATP-ase reaction was variable, slightly to moderately positive, in the same biopsy. Besides the dynein arm defect this is a second defect of another ATP-ase, located in the apical region of the ciliated and mucus producing epithelial cells. Based on histological examination of nasal mucosal biopsies a differential diagnosis has been established for Kartagener's syndrome, the more common cystic fibrosis and the relative frequent allergic rhinitis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenosinetriphosphatase - deficiency
- Adult - deficiency
- Child - deficiency
- Cilia - ultrastructure
- Comparative Study - ultrastructure
- Cystic Fibrosis - pathology
- Dynein ATPase - metabolism
- Female - metabolism
- Humans - metabolism
- Kartagener Syndrome - diagnosis
- Microscopy, Electron - diagnosis
- Nasal Mucosa - pathology
- Rhinitis, Allergic, Perennial - pathology