Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kärcher, H; McNally, NJ; Wilson, G; Kärcher, KH; Pfragner, R.
Flow cytometric measurements of in vivo incorporated bromodeoxy- uridine into the DNA of experimental and human tumors
WIEN KLIN WOCHENSCHR. 1985; 97(22): 850-855.
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Kärcher Hans
- Co-Autor*innen der Med Uni Graz
- Pfragner Roswitha
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- Abstract:
- A new cell kinetic method was used in vivo in an experimental mouse tumour and in human tumours of the oral cavity for the first time. The incorporation of BUdR into cells in the S-phase that are actively synthesizing DNA enables the determination of the rate of DNA synthesis from the amount of BUdR-related fluorescence using monoclonal antibody and the proportion of S-phase cells which are actively engaged in synthesis. The application of BUdR to the patients and the preparation of the tumour is reported.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - metabolism
- Animals - metabolism
- Antibodies, Monoclonal - diagnostic use
- Bromodeoxyuridine - metabolism
- DNA, Neoplasm - biosynthesis
- Flow Cytometry - biosynthesis
- Humans - biosynthesis
- Mice - biosynthesis
- Neoplasms, Experimental - metabolism