Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Finsterer, J; Stöllberger, C; Quasthoff, S.
Wolff-Parkinson-White syndrome as initial manifestation of Becker muscular dystrophy.
Herz. 2008; 33(4):307-310
Doi: 10.1007/s00059-008-3023-6
(- Case Report)
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Quasthoff Stefan
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- Abstract:
- BACKGROUND: Cardiac involvement may precede the onset of muscular manifestations in Becker muscular dystrophy (BMD), but Wolff-Parkinson-White (WPW) syndrome has not been reported as initial cardiac manifestation of BMD. CASE STUDY: In a 43-year-old, HIV-negative male, WPW syndrome was diagnosed at age 26 years upon a routine surface ECG, carried out for recurrent palpitations since childhood. Since then, WPW syndrome was occasionally found on repeated cardiologic follow-up investigations. From age 27 years, he developed proximal muscle weakness predominantly of the lower limbs, a positive Gower sign, and a waddling gait. Needle electromyograms were repeatedly myogenic, and upon reinvestigation at age 42 years, a deletion of exons 45-47 in the dystrophin gene was detected. Radiofrequency catheter ablation, initially refused by the patient, was scheduled again but no accessory pathways were detected on electrophysiological investigations. CONCLUSION: This case suggests that intermittent WPW syndrome may be a cardiac manifestation of BMD and that cardiac involvement may precede the development of evident skeletal muscle abnormalities.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Diagnosis, Differential -
- Electrocardiography -
- Humans -
- Male -
- Muscular Dystrophy, Duchenne - diagnosis
- Wolff-Parkinson-White Syndrome - diagnosis
- Find related publications in this database (Keywords)
- Muscular dystrophy
- Dystrophinopathy
- Heart
- Myocardium
- Electrocardiography
- Echocardiography
- X-linked inheritance