Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Leiberich, P; Nickel, MK; Tritt, K; Gil, FP.
Lamotrigine treatment of aggression in female borderline patients, Part II: an 18-month follow-up.
J Psychopharmacol. 2008; 22(7):805-808
Doi: 10.1177/0269881107084004
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- Nickel-Palczynski Marius
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- Abstract:
- Borderline patients often display pathological aggression. We previously tested lamotrigine, an anti-convulsant, in therapy for aggression in women with borderline personality disorder (BPD) (J Psychopharmacol 2005; 19: 287-291), and found significant changes on most scales of the State-Trait Anger Expression Inventory (STAXI) after eight weeks. To assess the longer-term efficacy of lamotrigine in therapy for aggression in women with BPD, this 18-month follow-up observation was carried out, in which patients (treated with lamotrigine: n = 18; former placebo group: n = 9) were tested every six months. According to the intent-to-treat principle, significant changes on all scales of the STAXI were observed in the lamotrigine-treated subjects. All subjects tolerated lamotrigine relatively well. Lamotrigine appears to be an effective and relatively safe agent in the longer-term treatment of aggression in women with BPD.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aggression - drug effects
- Antimanic Agents - adverse effects
- Borderline Personality Disorder - drug therapy
- Data Interpretation, Statistical -
- Female -
- Follow-Up Studies -
- Humans -
- Psychiatric Status Rating Scales -
- Treatment Outcome -
- Triazines - adverse effects
- Find related publications in this database (Keywords)
- borderline personality disorder
- aggression
- lamotrigine