Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Huppertz, B; Sammar, M; Chefetz, I; Neumaier-Wagner, P; Bartz, C; Meiri, H.
Longitudinal determination of serum placental protein 13 during development of preeclampsia.
Fetal Diagn Ther. 2008; 24(3):230-236
Doi: 10.1159/000151344
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Huppertz Berthold
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- OBJECTIVE: To determine maternal serum placental protein 13 (PP13) in normal pregnancy and preeclampsia. METHODS: A prospective, longitudinal study with 41 normal pregnant women, 18 cases with preterm delivery or cervix insufficiency and 4 with developing late-onset preeclampsia. Six hundred and sixty-six maternal blood samples were obtained every 2-4 weeks starting at 5-8 weeks gestation (10-12 samples/patient) and tested for serum PP13 by ELISA. RESULTS: In normal pregnant women delivering at term, median maternal serum PP13 levels were growing from 166 to 202 pg/ml and 382 pg/ml in the first, second and third trimester, respectively. Preeclamptic women had significantly reduced PP13 levels in the first trimester (multiples of median of 0.14 at 7-8 weeks; p = 0.005 compared to normal). PP13 in the third trimester was significantly higher compared to normal at 35-36 weeks with PP13 multiples of median of 1.79. CONCLUSION: This preliminary study indicates that low levels of PP13 in early pregnancy identify at-risk pregnancies, whereas high levels precede the syndrome in late pregnancy and suggest syncytiotrophoblast necrosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Biological Markers - blood
- Female -
- Galectins - blood
- Humans -
- Immunohistochemistry -
- Longitudinal Studies -
- Middle Aged -
- Placenta - metabolism
- Pre-Eclampsia - blood
- Pregnancy -
- Pregnancy Proteins - blood
- Pregnancy Trimester, First - blood
- Pregnancy Trimester, Second - blood
- Pregnancy Trimester, Third - blood
- Prospective Studies -
- Find related publications in this database (Keywords)
- preeclampsia
- placental protein 13
- placenta
- maternal serum
- prediction
- marker