Medizinische Universität Graz - Research portal
Selected Publication:
Schernthaner, G; Banatvala, JE; Scherbaum, W; Bryant, J; Borkenstein, M; Schober, E; Mayr, WR.
Coxsackie-B-virus-specific IgM responses, complement-fixing islet-cell antibodies, HLA DR antigens, and C-peptide secretion in insulin-dependent diabetes mellitus.
LANCET. 1985; 2(8456): 630-632.
Doi: 10.1016/S0140-6736(85)90003-0
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- Co-authors Med Uni Graz
- Borkenstein Helmuth Martin
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- Abstract:
- To evaluate the role of Coxsackie B viruses in the pathogenesis of insulin-dependent (juvenile-onset, type 1) diabetes mellitus (IDDM), attempts were made to correlate virus-specific IgM responses with HLA genes, autoimmune responses, and C-peptide secretion. HLA DR3, DR4, or both were present in 73 of 90 (81%) diabetic patients; 22 of 23 (96%) with Coxsackie-B-virus-specific IgM had at least one of these HLA types, compared with 51 of 67 (76%) without virus-specific IgM. There was no correlation between HLA A, B, or C types or immunoglobulin allotypes and virus-specific IgM responses. 16 of 22 (64%) patients with Coxsackie-B-virus-specific IgM compared with 26 of 72 (36%) without had complement-fixing islet-cell antibodies; no relation was found between virus-specific IgM and antibodies against thyroid or adrenal tissue or parietal cells. C-peptide secretion was significantly lower in patients with Coxsackie-B-virus-specific IgM.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adrenal Glands - immunology
- Adult - immunology
- Antibodies, Viral - biosynthesis
- Antibody Specificity - biosynthesis
- Autoantibodies - analysis
- C-Peptide - secretion
- Child - secretion
- Complement Fixation Tests - secretion
- Diabetes Mellitus, Type 1 - immunology
- Enterovirus B, Human - immunology
- HLA-DR Antigens - immunology
- Histocompatibility Antigens Class II - analysis
- Humans - analysis
- Immunoglobulin M - biosynthesis
- Insulin Antibodies - analysis
- Parietal Cells, Gastric - immunology
- Thyroid Gland - immunology