Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Holzer-Petsche, U; Schimek, E; Amann, R; Lembeck, F.
In vivo and in vitro actions of mammalian tachykinins.
Naunyn Schmiedebergs Arch Pharmacol. 1985; 330(2):130-135
Doi: 10.1007/BF00499905
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- Führende Autor*innen der Med Uni Graz
- Holzer Ulrike
- Co-Autor*innen der Med Uni Graz
- Lembeck Fred
- Reckenzaun Evelyn
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- Abstract:
- Recently, two kassinin-like tachykinins have been isolated from mammalian nervous tissue. The potencies of these peptides, substance K (neurokinin alpha) and neuromedin K (neurokinin beta) were compared with those of substance P, eledoisin, and kassinin in various pharmacological systems in vivo and in vitro. In contracting the isolated guinea-pig ileum and rabbit jejunum the potencies of eledoisin, kassinin, substance K, and neuromedin K were 13-80% that of substance P. In the rat vas deferens substance K and neuromedin K potentiated the electrically induced contractions with potencies similar to those of eledoisin and kassinin; they were 46-236 times as potent as substance P. In stimulating salivation in the rat after intravenous injection, eledoisin, kassinin, and substance K were respectively 2.3, 1.3 and 0.33 times as potent as substance P. In contrast, neuromedin K exhibited negligible activity. Each peptide tested led to a short fall in blood pressure after intravenous injection in the rabbit, substance P being 12-250 times as potent as the other peptides. Substance P was 20 times as potent as substance K or neuromedin K in inducing vasodilatation in the rat hind paw in vivo. Of the peptides tested, only substance P (10 nmol/min) significantly increased the release of histamine from the rat isolated hindquarter preparation. The results are discussed with respect to several theories of tachykinin receptor heterogeneity.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood Pressure - drug effects
- Eledoisin - pharmacology
- Female -
- Guinea Pigs -
- Hindlimb -
- Histamine Release - drug effects
- Ileum - drug effects
- Jejunum - drug effects
- Kassinin -
- Male -
- Muscle Contraction - drug effects
- Muscle, Smooth - drug effects
- Nerve Tissue Proteins - pharmacology
- Neurokinin A -
- Neurokinin B -
- Oligopeptides - pharmacology
- Rabbits -
- Rats -
- Rats, Inbred Strains -
- Salivation - drug effects
- Substance P - pharmacology
- Tachykinins -
- Vas Deferens - drug effects
- Vasodilation - drug effects