Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schulz, R; Post, H; Jalowy, A; Backenköhler, U; Dörge, H; Vahlhaus, C; Heusch, G.
Unique cardioprotective action of the new calcium antagonist mibefradil.
Circulation. 1999; 99(2):305-311
Doi: 10.1161/01.CIR.99.2.305
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Post Heiner
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: Mibefradil is a calcium antagonist with few negative inotropic effects at therapeutic concentrations. METHODS AND RESULTS: The effect of mibefradil on infarct size (IS) was compared with those of placebo, amlodipine, and verapamil in 64 anesthetized pigs. In placebo pigs, after 90 minutes of ischemia and 120 minutes of reperfusion, IS (by triphenyl tetrazolium chloride staining) was 15.3+/-10.8% (SD) of the area at risk. Mibefradil (0.60 mg/kg IV) reduced heart rate and left ventricular (LV) pressure, and IS was 1. 9+/-3.9% (P<0.05 versus placebo). Verapamil (0.15 mg/kg IV) also decreased heart rate, LV pressure, and IS (6.1+/-4.2%, P<0.05 versus placebo). Amlodipine (0.20 mg/kg IV) did not alter heart rate, LV pressure, or IS (9.9+/-5.4%, P=NS versus placebo). When heart rate was maintained constant by left atrial pacing and LV pressure was adjusted to that of the placebo group by an intra-aortic balloon, mibefradil still decreased IS (3.8+/-3.0%, P<0.05 versus placebo), but verapamil did not (11.6+/-8.3%, P=NS versus placebo). With glibenclamide infusion, mibefradil no longer reduced IS (13.1+/-4.3% versus 17.8+/-5.6% with glibenclamide alone, P=NS). CONCLUSIONS: The IS-limiting effect of mibefradil, in contrast to that of verapamil, was not dependent on favorable hemodynamics but was abolished by glibenclamide, suggesting a direct cardioprotective action of mibefradil.
- Find related publications in this database (using NLM MeSH Indexing)
- Amlodipine - pharmacology
- Animals - pharmacology
- Benzimidazoles - pharmacology
- Calcium Channel Blockers - pharmacology
- Glyburide - pharmacology
- Heart - drug effects
- Heart Rate - drug effects
- Heart Ventricles - drug effects
- Mibefradil - drug effects
- Myocardial Infarction - pathology
- Pressure - pathology
- Swine - pathology
- Tetrahydronaphthalenes - pharmacology
- Verapamil - pharmacology
- Find related publications in this database (Keywords)
- calcium
- mibefradil
- myocardial infarction