Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Neumann, T; Post, H; Ganz, RE; Walz, MK; Skyschally, A; Schulz, R; Heusch, G.
Linear and non-linear dynamics of heart rate variability in brain dead organ donors.
Z Kardiol. 2001; 90(7):484-491
Doi: 10.1007/s003920170137
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- Post Heiner
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- Abstract:
- Recent studies outlined linear and non-linear dynamics in heart rate variability; however, their physiological origin is still unknown. The present study investigated the impact of cerebral function on linear and non-linear dynamics in heart rate variability. Electrocardiograms from seven brain dead organ donors and seven healthy volunteers were analyzed. Atropine was used in healthy volunteers to adjust their heart rate to that of the donors. As compared to healthy volunteers without atropine, the linear dynamics of heart rate variability, determined by time and frequency domain analyses, were significantly reduced in healthy volunteers with atropine and, to an even greater extent, in donors. Atropine tended to increase the complexity and non-linearity of heart rate variability in healthy volunteers, as determined by the correlation dimension D and the largest Lyapunov exponent L, respectively (D = 9.43 +/- 2.93 vs. 7.65 +/- 0.97 and L = 0.525 +/- 0.099 vs. 0.504 +/- 0.047 bits.beat-1; both NS), while these indices were significantly reduced in donors by 19.5 +/- 12.8% and 15.0 +/- 11.7%, respectively (D = 6.16 +/- 0.98 and L = 0.428 +/- 0.059 bits.beat-1; both p < 0.05 vs. volunteers). Thus, loss of cerebral function reduces both linear and non-linear components of heart rate variability.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Brain Death -
- Data Interpretation, Statistical -
- Electrocardiography -
- Female -
- Heart Rate - physiology
- Humans - physiology
- Linear Models - physiology
- Male - physiology
- Middle Aged - physiology
- Nonlinear Dynamics - physiology
- Tissue Donors - physiology
- Find related publications in this database (Keywords)
- heart rate variability
- organ donors
- correlation dimension
- largest Lyapunov exponent