Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zollner-Schwetz, I; Högenauer, C; Joainig, M; Weberhofer, P; Gorkiewicz, G; Valentin, T; Hinterleitner, TA; Krause, R.
Role of Klebsiella oxytoca in antibiotic-associated diarrhea.
Clin Infect Dis. 2008; 47(9):e74-e78
Doi: 10.1086/592074
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- Führende Autor*innen der Med Uni Graz
- Zollner-Schwetz Ines
- Co-Autor*innen der Med Uni Graz
- Gorkiewicz Gregor
- Hinterleitner Thomas
- Hoegenauer Christoph
- Joainig Martina
- Krause Robert
- Valentin Thomas
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- Abstract:
- Klebsiella oxytoca was recently shown to be the causative agent of antibiotic-associated hemorrhagic colitis. Because it is unclear whether K. oxytoca also causes nonhemorrhagic antibiotic-associated diarrhea, our study investigated a possible association between K. oxytoca and that disorder. A total of 371 consecutive patients were recruited into 4 study groups: (1) group A+D+ (patients who received antibiotics and experienced diarrhea; n = 107), (2) group A+D- (patients who received antibiotics but did not experience diarrhea; np93), (3) group A-D+ (patients who experienced acute-onset diarrhea but did not receive antibiotics; n = 60), and (4) group A-D- (patients without diarrhea who did not receive antibiotics; n = 111). Stool samples were plated on MacConkey agar and K. oxytoca was identified using a standard test kit. Clostridium difficile was detected by a toxin A/B antigen test. K. oxytoca strains were tested for cytotoxicity with use of cell-culture assays. In 15 of 371 stool samples, K. oxytoca strains were isolated during the study period. There was no significant difference in the distribution of K. oxytoca among the 4 study groups. Six of the 15 strains were found to be toxin producing. Three of the toxin-producing strains caused antibiotic-associated hemorrhagic colitis. No case of nonhemorrhagic antibiotic-associated diarrhea due to toxin-producing K. oxytoca was detected. K. oxytoca is not the causative agent of nonhemorrhagic antibiotic-associated diarrhea. This is in contrast to the distinct clinical entity of antibiotic-associated hemorrhagic colitis. Testing for K. oxytoca is therefore only warranted for patients who experience bloody diarrhea during antibiotic therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Anti-Bacterial Agents - adverse effects
- Bacterial Toxins - biosynthesis
- Case-Control Studies -
- Clostridium difficile - isolation & purification
- Clostridium difficile - pathogenicity
- Diarrhea - etiology
- Diarrhea - microbiology
- Enterocolitis, Pseudomembranous - etiology
- Enterocolitis, Pseudomembranous - microbiology
- Female -
- Humans -
- Klebsiella Infections - etiology
- Klebsiella Infections - microbiology
- Klebsiella oxytoca - isolation & purification
- Klebsiella oxytoca - metabolism
- Klebsiella oxytoca - pathogenicity
- Male -
- Middle Aged -