Medizinische Universität Graz - Research portal
Selected Publication:
Aglas, F; Rainer, F; Lipp, RW; Schnedl, WJ; Horn, S; Egger, G.
Effect of steroid treatment on the migration behaviour of neutrophils in patients with early rheumatoid arthritis.
Rheumatol Int. 1997; 17(4):137-140
Doi: 10.1007/s002960050024
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Egger Gerd
- Horn Sabine
- Lipp Rainer
- Schnedl Wolfgang
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- Abstract:
- The influence of methylprednisolone on the migratory characteristics of neutrophil granulocytes was investigated in 10 patients with early rheumatoid arthritis (RA) and compared to 12 controls. The migration of neutrophils was measured with a whole-blood membrane filter assay with and without stimulation by the chemoattractant N-formyl-methionyl-leucyl-phenylalanine (fMLP). Total migration index (TMI), distribution characteristics (DC) and the product of TMI and DC (neutrophil migratory activity; NMA) served to characterize the migratory behaviour of neutrophils. The data demonstrated an increased polymorphonuclear leucocyte (PMN) migration in patients with early RA, indicating a bystander role of PMNs in inflammatory joint injury. Treatment with methylprednisolone reduced significantly the penetration depth (DC) of neutrophils, but did not influence the number of migrating cells (TMI). The unstimulated NMA was significantly reduced due to the marked DC reduction, whereas steroids did not influence the stimulated NMA of neutrophils. A significant reduction in PMN penetration depth was demonstrated only after a steroid therapy of at least 10 days, suggesting that a longer period of steroid therapy is necessary to provide effective inflammatory control.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Anti-Inflammatory Agents - therapeutic use
- Arthritis, Rheumatoid - drug therapy
- Arthritis, Rheumatoid - immunology
- Cells, Cultured -
- Chemotaxis, Leukocyte - physiology
- Female -
- Humans -
- Male -
- Methylprednisolone - therapeutic use
- Middle Aged -
- N-Formylmethionine Leucyl-Phenylalanine - pharmacology
- Neutrophils - drug effects
- Neutrophils - physiology
- Find related publications in this database (Keywords)
- Steroid Therapy
- Early Rheumatoid Arthritis
- Polymorphonuclear Leukocytes
- Migration