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Cvirn, G; Kutschera, J; Wagner, T; Ferstl, U; Vrecko, K; Hallstrom, S; Juergens, G; Koestenberger, M.
Collagen/endogenous thrombin-induced platelet aggregation in cord versus adult whole blood.
Neonatology. 2009; 95(2): 187-192.
Doi: 10.1159/000155613
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Cvirn Gerhard
- Co-authors Med Uni Graz
- Ferstl Ulrika
- Hallström Seth
- Jürgens Günther
- Koestenberger Martin
- Vrecko Karoline
- Wagner Thomas
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- Abstract:
- Background: In previous studies, neonatal platelets have been shown to be hypoaggregable to various agonists when compared with adult platelets. Objectives: It was the aim of this study to investigate the aggregability of neonatal versus adult platelets when the physiological relevant agonist collagen/endogenous thrombin is used. Methods and Results: Whole blood (WB) aggregation experiments employing the impedance method revealed the same responsiveness of neonatal and adult platelets to collagen/endogenous thrombin. Maximum aggregation (13.5 +/- 3.2 vs. 13.6 +/- 3.2 Omega; p = 0.94), slope (5.8 +/- 1.8 vs. 6.2 +/- 2.6 Omega/min; p = 0.79) and lag time until the onset of platelet aggregation (38.7 +/- 8.9 vs. 42.6 +/- 16.5 s; p = 0.59) were similar in cord and adult WB. However, the rise in serotonin plasma levels due to platelet activation was significantly lower in neonates versus adults (227.57 +/- 57.65 vs. 473.34 +/- 155.75 ng/ml; p = 0.0001). Furthermore, we found a fast capability of cord plasma to generate (the efficient platelet agonist) endogenous thrombin: thrombin generation started significantly earlier in cord compared with adult plasma (215 +/- 19 vs. 247 +/- 21 s; p = 0.01). Moreover, thrombelastometry revealed significantly shorter coagulation times in cord versus adult WB activated with collagen/endogenous thrombin (229.8 +/- 12.5 vs. 256.3 +/- 25.3 s; p = 0.003). Conclusions: The efficient platelet aggregation in cord WB provoked by collagen/endogenous thrombin might help to explain the clinically observed well-functioning primary hemostasis of neonates. Copyright (c) 2008 S. Karger AG, Basel
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age Factors -
- Blood Coagulation -
- Blood Platelets - physiology
- Collagen - physiology
- Fetal Blood - physiology
- Humans -
- Infant, Newborn -
- Middle Aged -
- Platelet Aggregation - physiology
- Reference Values -
- Serotonin - blood
- Thrombelastography - methods
- Thrombin - physiology
- Young Adult -
- Find related publications in this database (Keywords)
- Cord and adult whole blood
- Thrombelastometry
- Thrombin generation
- Whole blood aggregomet