Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schreibmayer, W; Tritthart, HA; Zernig, G; Piper, HM.
Single voltage-dependent and outward rectifying K+-channels in isolated rat heart cells.
Eur Biophys J. 1985; 11(4):259-263
Doi: 10.1007/BF00262003
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- Führende Autor*innen der Med Uni Graz
- Schreibmayer Wolfgang
- Co-Autor*innen der Med Uni Graz
- Tritthart Helmut
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- Abstract:
- Studies on single K+-channel currents recorded from isolated rat heart muscle cells, in which early repolarization is known to be exceptionally fast, are reported here. A K+-channel which is blocked by TEA (tetraethylammonium) from the inside only has been found. The total open time of the channel, measured in steady-state after activation, indicated outward rectifying properties. The single channel conductance increases with depolarization from 25 pS at -70 mV to 75 pS at + 70 mV. Selectivity of the channel has also been measured and it was found that only Rb+ and K+ can permeate the channel, whereas the permeability (P) for Li+, Na+, Cl-, Mg2+, and Ca2+ is less than 0.05 times PK+. Ba2+ and CS+ block the channel activity. These results clearly demonstrate the existence of K+-selective outward rectifying conductance pathways in rat ventricular myocytes.
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