Medizinische Universität Graz - Research portal
Selected Publication:
Zach, MS; Oberwaldner, B; Forche, G; Polgar, G.
Bronchodilators increase airway instability in cystic fibrosis.
AMER REV RESP DIS. 1985; 131(4): 537-543.
Doi: 10.1164/arrd.1985.131.4.537
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Leading authors Med Uni Graz
- Zach Maximilian
- Co-authors Med Uni Graz
- Oberwaldner Beatrice
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Supramaximal flow transients of partial expiratory flow-volume curves are caused by a rapidly emptying compartment. By superimposing a maximal and a series of partial expiratory flow-volume curves, the volume of the flow transient equivalent for the maximal curve was estimated (volume of airway contribution = VACMEFV). This flow transient equivalent is caused by an extra dead space, created in the large airways by a full inspiration. In 18 children with cystic fibrosis (CF), routine pulmonary functions and VACMEFV were measured before and after bronchodilator medication. Baseline VACMEFV correlated directly with the curvilinearity of the flow-volume curve and inversely with the clinical and radiologic score. Significantly, bronchodilator medication improved FVC, FEV1, FEF25-75, VC, PEF, Raw, and also VACMEFV. In 6 children, VEmax25 increased as a result of apparent peripheral bronchodilation. In 3 others, end-expiratory flow increased slightly but the expanded VACMEFV included the measuring point invalidating the measurement. In the remaining 9 patients, VEmax25 decreased after bronchodilator. As an apparent discrepancy, FEV1, FVC, PEF, VC, FEF25-75 increased, and Raw decreased in 4 to 9 patients. The volumes and flow rates measured early in forced expiration and the end-expiratory flow behaved differently because VACMEFV expanded beyond the measuring points of early expiratory and mid-expiratory flow rates. As the bronchodilator rendered the compliant large airways still more distensible, the amount of air emptied from the dead space in early forced expiration increased. Simultaneously, end-expiratory flow decreased because of enhanced airway compression.(ABSTRACT TRUNCATED AT 250 WORDS)
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Asthma - physiopathology
- Bronchodilator Agents - pharmacology
- Child - pharmacology
- Cystic Fibrosis - physiopathology
- Female - physiopathology
- Humans - physiopathology
- Lung Compliance - drug effects
- Lung Volume Measurements - drug effects
- Male - drug effects
- Maximal Expiratory Flow-Volume Curves - drug effects
- Peak Expiratory Flow Rate - drug effects
- Pulmonary Ventilation - drug effects
- Respiratory Function Tests - drug effects
- Vital Capacity - drug effects