Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Miyati, T; Mase, M; Kasai, H; Hara, M; Yamada, K; Shibamoto, Y; Soellinger, M; Baltes, C; Luechinger, R.
Noninvasive MRI assessment of intracranial compliance in idiopathic normal pressure hydrocephalus.
J Magn Reson Imaging. 2007; 26(2):274-278
Doi: 10.1002/jmri.20999
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Söllinger Michaela
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- Abstract:
- PURPOSE: To assess the state and dynamics of the intracranial system in idiopathic normal-pressure hydrocephalus (I-NPH), we determined intracranial compliance using magnetic resonance imaging (MRI). MATERIALS AND METHODS: The intracranial compliance index (ICCI), which was defined as the ratio of the peak-to-peak intracranial volume change (ICVC(p-p)) to the peak-to-peak cerebrospinal fluid (CSF) pressure gradient (PG(p-p)) during the cardiac cycle, was obtained from the net transcranial blood and CSF flow measured with phase-contrast (PC) cine MRI. ICCI was determined in patients with I-NPH (N = 7), brain atrophy, or asymptomatic ventricular dilation (VD) (N = 6), and in healthy volunteers (control group; N = 11). The changes in ICCI indices were also analyzed after a CSF tap test (N = 2). RESULTS: The ICCI in the I-NPH group was significantly lower than in the control and VD groups, whereas no difference was found between the control and VD groups. The ICVC(p-p) was also lower than in the control and VD groups. However, no significant difference was found in the PG(p-p) between groups. The ICCI increased after the tap test. CONCLUSION: Intracranial compliance analysis with MRI makes it possible to noninvasively obtain more detailed information of intracranial biomechanics in the I-NPH and to assist in the diagnosis of I-NPH.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Biomechanics -
- Brain - pathology
- Case-Control Studies - pathology
- Female - pathology
- Humans - pathology
- Hydrocephalus, Normal Pressure - diagnosis
- Image Processing, Computer-Assisted - diagnosis
- Magnetic Resonance Imaging - methods
- Male - methods
- Middle Aged - methods
- Reference Values - methods
- Reproducibility of Results - methods
- Find related publications in this database (Keywords)
- intracranial compliance
- idiopathic normal pressure hydrocephalus
- pressure gradient
- intracranial volume loading
- brain atrophy
- tap test