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Selected Publication:
Gadner, H; Krepler, P; Kummer, M; Pawlovsky, J; Schmidmeier, W; Haas, OA; Grümayer, ER; Ausserer, B; Bettelheim, P; Grienberger, H.
Cooperative studies in the treatment of acute lymphoblastic leukemia in children in Austria--report of 10 years' experience
WIEN KLIN WOCHENSCHR. 1985; 97(3): 140-148.
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- Co-authors Med Uni Graz
- Jürgens Günther
- Urban Ernst-Christian
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- Abstract:
- 437 children with acute lymphoblastic leukaemia (ALL) have been treated at 9 different institutions in Austria utilizing common protocols and central registration between 1974 and 1984. 227 patients (132 boys and 95 girls, group I) were treated between 1974 and 1980 using 3 consecutive protocols (KMK, O 76, A 78), which were essentially derived from the Memphis studies VII and VIII. Patients with a high risk of relapse were treated according to the LSA 2-L2 protocol. 210 patients (112 boys and 98 girls, group II) were consecutively treated following the BFM protocols 76/79 and 81/83. In this group, treatment intensity was adjusted to the initially determined individual risk of relapse (BFM risk score or risk factor). To date, the life table analysis demonstrates that the probability of continuous complete remission for patients in group II is 60% after 5 and 3 years (BFM 76/79 and BFM 81/83, respectively), whereas group I reaches a level of 37.3%. The prognostic difference between risk and non-risk patients in both studies of group II was eliminated. Despite a higher morbidity and non-leukaemia-related mortality in group II, the therapeutic success can be attributed to the intensification of induction therapy.
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