Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Stöger, H; Schmid, M; Bauernhofer, T; Moser, R; Ploner, F; Derstvenscheg, E; Kasparek, AK; Kuss, I; Wilders-Truschnig, M; Lackner, C.
A phase II trial of weekly high-dose folinic acid and 5-fluorouracil in combination with epirubicin as salvage chemotherapy in advanced breast cancer.
Oncology. 1994; 51(6):518-522
Doi: 10.1159/000227397
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- Führende Autor*innen der Med Uni Graz
- Stöger Herbert
- Co-Autor*innen der Med Uni Graz
- Bauernhofer Thomas
- Kasparek Anne-Katrin
- Lackner Karoline
- Ploner Ferdinand
- Samonigg Hellmut
- Schaberl-Moser Renate
- Truschnig-Wilders Martini
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- Abstract:
- Twenty-five patients with advanced breast cancer (ABC) who had failed from first-line chemotherapy entered into a phase II study employing weekly 5-fluorouracil (FU) 350 mg/m2, folinic acid (FA) 500 mg/m2, and epirubicin (EPI) 35 mg/m2, for a maximum of 18 cycles. Twenty-three patients were evaluable for response. One achieved a complete response and 7 showed a partial response, for an objective response rate of 35%; 7 (31%) patients achieved a stabilization of the disease, while 8 (35%) patients progressed under treatment. The median duration of response was 6 months and median survival amounted to 10.6 months. Side effects were in general mild with grade III leukopenia in 5 patients and grade IV leukopenia in 1 patient. Other toxicity included nausea and vomiting (88%), diarrhea (26%), stomatitis (40%) and alopecia (84%), but all of them mainly restricted to WHO grade I and II. Our results suggest that the combination of high-dose FA, FU, and EPI can be safely administered in the investigated schedule and represents an attractive alternative in the search for second-line therapies that combine effectiveness with acceptable toxicity in the treatment of refractory ABC.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antineoplastic Combined Chemotherapy Protocols - adverse effects
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Breast Neoplasms - drug therapy
- Drug Administration Schedule -
- Epirubicin - administration & dosage
- Female -
- Fluorouracil - administration & dosage
- Humans -
- Leucovorin - administration & dosage
- Middle Aged -
- Salvage Therapy -
- Find related publications in this database (Keywords)
- Folinic Acid
- Fluorouracil
- Epirubicin
- Weekly Schedule
- 2nd-Line Therapy
- Advanced Breast Cancer